ITE Synthetic and Medicinal Chemistry

Who We Are

In 2010, as part of its economic development mission, the University of Missouri – St. Louis has developed a core chemistry facility called the Synthetic and Medicinal Chemistry Group. The MCG works within the University of Missouri System to support researchers in gaining new grant funding and in advancing intellectual property.  MCG also collaborates with other universities and commercial entities. MCG offers industry-class equipment and expertise typically available in industrial pharmaceutical lead compound labs. The Medicinal Chemistry Group works via grants and contracts in collaboration with academic and industry partners — please contact Michael Hayes, to see how the MCG can help your company move forward.

Mission:

The Synthetic and Medicinal Chemistry Group (MCG) aims to apply its expertise in synthetic, organic, and medicinal chemistry to solve problems by translating researchers’ discoveries into affordable, accessible, and clinically useful therapies.

 

Services and Capabilities

MCG provides an array of chemistry services to industry and university researchers. Contract opportunities include fee-for-service work for known chemistry, as well as research contracts for novel chemistry.

MCG has assisted on grants including SBIRs, STTRs, RO1 and other mechanisms.

These services include:

  • Medicinal Chemistry Strategies
    • ADMET properties maximization
    • Lead optimization
    • Scale-up synthesis of lead compounds / advanced intermediates
  • Custom Synthesis Options
    • Tool compounds
    • Metabolites
    • Lead optimization
    • New molecules
    • Intermediates
    • Small batch production
  • Consultation
    • Process development
    • Route optimization
    • Pharmaceutical patent analysis

 

Laboratory and Instrumentation

The MCG facility is outfitted with all the equipment of a modern industrial lab.

  • Laboratory
    • Two six-foot fume hoods
      • Water/gas/compressed air
    • In house millipore water purification system
    • Access to NMR and IR spectroscopy
    • Dry ice/liquid nitrogen
  •  Instrumentation
    • HPLC-MS
    • Analytical Agilent HPLC instruments
    • Gilson reverse phase chromatography
    • Flash Master normal phase chromatography
    • Library synthesis equipment
    • Virtis lyophilyzer
    • Genevac personal evaporator
    • Polarimeter
    • Sonicator

 

Collaborations and Clients

The MCG looks to apply our expertise in synthetic organic and medicinal chemistry to solve problems in a wide range of research areas. We are actively seeking partnerships and collaborations with both academic and industry investigators. Current and former collaborators include:

Universities and Grant Collaborators

  • Washington University
    • Dr. Wayne Barnes
    • Dr. John DiPersio
  • Saint Louis University
    • Center for World Health and Medicine
    • Dr. John Burris
    • Dr. John K. Walker
  • University of Missouri
    • Dr. George Gokel
    • Dr. Peter Koulen
    • Dr. Hongmin Sun

Industry and Fee for Service

  • Akermin
  • Confluence
  • Biomed Valley
  • Emmyon
  • Millennium
  • Diapeutix
  • Sigma Millipore
  • Innovimmune
  • Midway Animal Health

Contact

Michael J. Hayes, M.S., Manager & Research Scientist, Medicinal Chemistry Group at the University of Missouri-St. Louis

(314) 516-4888

The MCG is located at ITE: Innovative Technology Enterprises
2.4 miles from the UMSL campus
4633 World Parkway
St. Louis, MO 63134
hayesmj@umsl.edu

Mike

Utilizing his twelve years of industrial experience with Pfizer, Michael is a highly skilled medicinal and synthetic organic chemist. In addition to extensive experience in the design and synthesis of bioactive molecules, he has routinely performed multi-step, combinatorial, and scale-up synthesis of numerous drug candidates. During his time in the pharmaceutical industry, Michael worked on multiple therapeutic targets such as kinases, cannabinoids, synthases, and glucocorticoid receptor modulators for the treatment of cardiovascular conditions as well as inflammation and pain. Incorporation of traditional structure activity relationship (SAR) analysis, and computer software based design tools with his expertise in the laboratory, make Michael a highly valued member of the team. Michael earned both a B.S. and M.S. degree in Chemistry from Illinois State University. He has co-authored 10 peer reviewed publications and 11 patents.